PRIMECHEMICAL · SCIENCE

Science

Peer-reviewed research on creatine, protein and sweetening systems — read, charted and translated into what it means for a formulator. Every claim traced back to its PubMed source.

Analytical laboratory bench with chromatography equipment, of the kind used to separate a steviol glycoside profile rather than report a single total-glycosides figure.
Evidence review

Sweeteners and blood pressure: the comparator decides

A 2026 meta-analysis of 18 trials reports resting systolic pressure 3.25 mmHg lower with non-nutritive sweeteners. A second 2026 synthesis finds nothing. The comparator explains it.

22 Oct 2026 · 12 min
Analytical laboratory bench with chromatography equipment, of the type used to verify the identity and purity of a creatine monohydrate lot. Cognitive outcomes are not measured here, but in clinical trials.
Creatine

Creatine and cognition: the claim the EU refused

A 2024 meta-analysis reported a memory effect for creatine. Its memory estimate pooled 1,000 participants from a review of 492. EFSA disagreed, and in 2026 the...

15 Oct 2026 · 12 min
Analytical quality control laboratory: HPLC bench of the type used to assay food ingredient lots before release.
Evidence review

Sugar reduction with sweeteners: what 14 trials show

Replacing sugar-sweetened drinks with sweetened ones moved body weight by 0.73 kg across 14 randomised trials. Glycaemic markers barely moved. What that means for a sugar-reduction...

29 Sep 2026 · 13 min
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